The informed agreement of the custodial parents to raise the dosage of depression medication is the first ethical factor to be taken into account. The majority of pediatric psychiatric drugs have been administered off-label, that is, without the required scientific research to result in FDA clearance. First and foremost, there is a serious worry about the effects of earlier and longer pharmacological intervention on developing brains (Lupien et al., 2018). There is proof that using neuroleptics and other psychotropic drugs results in long-lasting, if not permanent, alterations to the brain’s structure (Lupien et al., 2018).

Conclusion

The patient in the described scenario is an 8-year-old African American boy who comes to the emergency room with his mother. He is displaying depressive symptoms. The patient reports feeling sad, and the mother says the teacher has noted the child’s withdrawal from classmates, decreased appetite, and sporadic irritability. For depression, Zoloft 25 mg orally daily was chosen as the initial treatment option. 

Informed parental agreement to begin taking depression medication is the first ethical factor to be taken into account. The FDA insists that Zoloft is an off-label antidepressant drug for youngsters. Increase dosage to 50 mg of Zoloft daily under the second treatment strategy. The third course of action is to up the dose to 75 mg. The amount of reduction has now been sufficiently reduced. Consideration of a therapeutic response is based on sufficient symptom relief.

References

Dwyer, J., Stringaris, A., Brent, D., & Bloch, M. (2020). Annual Research Review: Defining and treating pediatric treatmentā€resistant depression. Journal Of Child Psychology And Psychiatry61(3), 312-332. https://doi.org/10.1111/jcpp.13202

Dwyer, J. B., & Bloch, M. H. (2019). Antidepressants for Pediatric Patients. Current Psychiatry18(9), 26–42F. https://doi.org/10.1002/pds.5358

Gebauer-Bukurovx, K., Nikolasevic, Z., Hajder, D., Zivanovic, Z., & Bugarski Ignjatovic, V. (2019). Evaluation of symptoms of depression and anxiety in adolescents with epilepsy in a Tertiary-Level Medical Center in Serbia. Annals Of Indian Academy Of Neurology0(0), 0. https://doi.org/10.4103/aian.aian_239_18

Hengartner, M. (2020). Editorial: Antidepressant Prescriptions in Children and Adolescents. Frontiers In Psychiatry11. https://doi.org/10.3389/fpsyt.2020.600283

Kweon, K., & Kim, H. (2019). Effectiveness and Safety of Bupropion in Children and Adolescents with Depressive Disorders: A Retrospective Chart Review. Clinical Psychopharmacology And Neuroscience17(4), 537-541. https://doi.org/10.9758/cpn.2019.17.4.537

Lai, L., Vuong, D., Ting, A., Dang, L., Ngo, V., Jo, Y., & Zhou, W. (2018). Off-Label Drug Use in Children and Adolescents with Depressive Disorder. Value In Health, 21, S146. https://doi.org/10.1016/j.jval.2018.04.1006

Lewis, S., Arseneault, L., Caspi, A., Fisher, H., Matthews, T., & Moffitt, T. et al. (2019). The epidemiology of trauma and post-traumatic stress disorder in a representative cohort of young people in England and Wales. The Lancet Psychiatry6(3), 247-256. https://doi.org/10.1016/s2215-0366(19)30031-8

Lupien, S., Juster, R., Raymond, C., & Marin, M. (2018). The effects of chronic stress on the human brain: From neurotoxicity, to vulnerability, to opportunity. Frontiers In Neuroendocrinology49, 91-105. https://doi.org/10.1016/j.yfrne.2018.02.001

Singh, S., Roy, D., Sinha, K., Parveen, S., Sharma, G., & Joshi, G. (2020). Impact of COVID-19 and lockdown on mental health of children and adolescents: A narrative review with recommendations. Psychiatry Research293, 113429. https://doi.org/10.1016/j.psychres.2020.113429

Spence, O., Reeves, G., & dosReis, S. (2021). Evaluating the association between antidepressant dose trajectories and treatment augmentation in pediatric depression. Pharmacoepidemiolog


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